Chronic Inflammation: Diet, Vagus Nerve, Environment, and Blood Sugar Interventions - Episode Hero Image

Chronic Inflammation: Diet, Vagus Nerve, Environment, and Blood Sugar Interventions

Original Title:

TL;DR

  • Chronic inflammation is the primary driver of disease in the United States, impacting physical and mental health by causing conditions like joint pain, brain fog, depression, and neurobehavioral delays.
  • Gluten and dairy are identified as the most common dietary triggers for inflammation in patients with chronic diseases, due to immune system confusion between casein and gluten proteins.
  • Stimulating the vagus nerve through methods like aggressive gargling or gagging can improve digestion, increase natural digestive enzymes, and reduce inflammation by activating the parasympathetic nervous system.
  • Environmental factors such as cleaning supplies, laundry detergents, and mold exposure significantly contribute to inflammatory load, with mold being a critical issue that must be addressed for health improvement.
  • Over-sanitization and excessive use of antibiotics can disrupt the microbiome and immune system, potentially leading to increased susceptibility to autoimmune conditions and other health problems.
  • Stabilizing blood glucose levels within a range of 80-130 mg/dL is a critical intervention for reducing inflammation and improving overall health, impacting energy levels and cognitive function.
  • Regenerative medicine, particularly stem cell injections and disc replacement surgery, offers significant potential for healing injuries, reducing pain, and improving quality of life for patients with joint and spinal issues.

Deep Dive

Chronic inflammation is a pervasive driver of disease and diminished quality of life, stemming primarily from dietary triggers, blood sugar dysregulation, and a compromised gut. Addressing inflammation requires a multifaceted approach that prioritizes real food, optimizes digestion, and calms the nervous system, ultimately leading to significant improvements in physical and mental well-being.

The core of an inflamed lifestyle lies in food choices, with gluten, dairy, and sugar identified as the most common culprits that trigger inflammatory responses. These foods can confuse the immune system, leading to a cascade of issues that manifest as joint pain, brain fog, fatigue, and even depression, impacting individuals across all age groups. Measuring inflammation involves tracking markers like C-reactive protein, homocysteine, and ferritin, which provide concrete data on the body's inflammatory load.

Beyond diet, the nervous system plays a critical role. Stimulating the vagus nerve through techniques such as aggressive gargling, deep breathing, or cold exposure can enhance digestive enzyme production, increase stomach acid, and improve gut motility, directly addressing root causes of food sensitivities. This neural connection also highlights how environmental factors, including exposure to toxins in cleaning supplies and personal care products, can contribute to inflammation and autoimmune conditions by triggering immune system responses.

Furthermore, the modern obsession with sterility, while well-intentioned, may be detrimental. The "hygiene hypothesis" suggests that limited exposure to microbes can hinder the immune system's development, making individuals more susceptible to inflammation and disease. Similarly, while regenerative medicine, particularly stem cell treatments, shows promise for injuries and joint issues, its effectiveness is enhanced when combined with foundational health practices like diet and lifestyle changes. The key takeaway is that a proactive, integrated approach to managing inflammation, focusing on personalized dietary and lifestyle interventions, is essential for long-term health and vitality.

Action Items

  • Audit dietary triggers: For 30 days, eliminate gluten, dairy, and sugar, then reintroduce foods one by one to identify personal inflammatory triggers.
  • Implement vagal nerve stimulation: Practice aggressive gargling for 2-3 minutes daily to improve digestion and reduce inflammation.
  • Analyze environmental load: Identify and replace 2-3 common household products (e.g., cleaning supplies, laundry detergent) with natural alternatives to reduce toxic exposure.
  • Track blood sugar stability: Use a continuous glucose monitor for 1-2 weeks to understand how food choices impact blood sugar levels and inflammation.

Key Quotes

"So inflammation single-handedly causing more disease in this country than anything else. And you're right, where it is loosely termed, but in reality, I see with my ten clinics probably 350 patients a day, and we see patients from all over the world that are suffering from severe chronic conditions. And in reality, when they come to us, we look at a bunch of other physiological imbalances, but what we're really getting to is what's causing inflammation? Do they have inflammation? What's triggering it? What's causing it? And how can we get it to calm down?"

Dr. Josh Redd emphasizes that inflammation is the root cause of numerous diseases, impacting a vast number of patients he sees daily. He explains that identifying and calming inflammation is the primary goal in treating severe chronic conditions, leading to significant improvements in patients' quality of life.


"Yeah, I think a lot of different ways: joint pain, intestinal problems, brain fog, depression. Like the way we're treating depression right now is if you have a decreased neurotransmitter, you just replace it. And that's old school. Right now, we're seeing that if you have brain inflammation, then it decreases all neurotransmitters and causes tons of problems. So even depression, fatigue, anxiety, restlessness, neurobehavioral issues, it's felt in a ton of different ways."

Dr. Josh Redd details how inflammation manifests physically and mentally, extending beyond typical symptoms like joint pain. He highlights that brain inflammation can lead to decreased neurotransmitters, causing issues like depression, fatigue, and anxiety, which are often overlooked or misdiagnosed.


"Gluten. Gluten's hands down the worst one. And then the second one is dairy, and then sugar. And obviously there's, there's kind of a difference between conventional dairy and whole milk and things like that, but mainly just conventional dairy that really jacks up our patients. And with research, it shows that the casein protein, which is the dairy protein, it mimics the gluten protein pretty similarly. And so our immune system gets confused, and those two are kind of go hand in hand to be in some of the most common inflammatory triggers for our patients."

Dr. Josh Redd identifies gluten and dairy as the most common inflammatory triggers for his patient population, explaining that the casein protein in dairy mimics gluten, confusing the immune system. He notes that sugar also contributes significantly to inflammatory problems.


"A hundred percent. Yeah. And that's kind of the big goal for us is we want to address what their specific inflammatory foods are versus the next patient. Everyone has a little bit different foods that they react to for some reason or another. But the most common overall in a general standpoint is dairy and gluten. And then obviously there's sugar, insulin surges and and all that stuff causes a lot of inflammatory problems and issues too. But those three are probably the top that we see."

Dr. Josh Redd reiterates that while dairy and gluten are generally the most common inflammatory triggers, individual reactions vary. He emphasizes that identifying a patient's specific food triggers is a key goal, alongside managing sugar intake and blood sugar stability, to reduce overall inflammation.


"Yeah, I love digestive enzymes because you're just aiding in helping those food proteins break down, right? So you're minimizing the workload that your body will have to do, especially if we're eating inflammatory foods. What I like to do even better though is to get to the mechanism of why they don't have the proper digestive enzymes functioning, right? A lot of people don't know, and a lot of like health practitioners out there, they'll see a lot of chronic severe cases, and they'll work with the stomach, the liver, the hormones, the blood sugar levels, but they completely neglect the brain."

Dr. Josh Redd explains that while digestive enzymes can aid in breaking down food proteins, he prioritizes addressing the root cause of poor enzyme function, which often lies in the brain. He points out that many practitioners overlook the brain's role in signaling the digestive system, leading to insufficient enzyme production.


"Yeah, yeah. So a lot of different ways that you can do that. Um, one is gargling aggressively for two to three minutes. Uh, you can stimulate the vagal nuclei. I have a hilarious story, by the way. So I had a patient just recently, she was constipated, and she was a new patient. Uh, and we had her start the anti-inflammatory diet and some supplements to help improve some things. And, um, she's like, "Dr. Redd, I'm constipated." And I was like, "Okay, well, um," she's like, "Can I take anything to help with the constipation?" And I said, "Well, how about we do this? Just, just gargle water aggressively for two to three minutes every hour until you go to bed." It was like at 5:00 PM. And she's like, "Okay, I'll do that." Um, and all of a sudden, I got a text, "Dr. Redd, I pooped." But just by, you know, doing that, that stimulates the vagal nuclei and then stimulates blood flow to the gut and will help gut motility and all that stuff. And it works."

Dr. Josh Redd shares a patient anecdote to illustrate the power of vagal nerve stimulation through aggressive gargling. He explains that this action stimulates the vagal nuclei, which in turn enhances blood flow to the gut and improves motility, effectively resolving constipation in this case.


"Well, we're constantly being exposed to different things. And I'll preface this, there's, there might be some people that listen to this like, 'Oh my gosh, I can't make all these changes all at once.' And I would just preface, just start with one easy change that you can make and then look to improve it. And the same thing goes with your home, right? Where if you go into your home and you're using, um, soap that's full of artificial and synthetic things that are hazardous to your health, just get a more natural soap, right? Or, um, laundry detergent, for example, get a more natural laundry detergent."

Dr. Josh Redd advises a gradual approach to cleaning up one's home environment, suggesting starting with simple swaps like using natural soaps or laundry detergents. He emphasizes that reducing exposure to artificial and synthetic chemicals in household products lowers one's environmental and inflammatory load.


"A thousand percent. Yes. I mean, you look at like COVID, dude. I can, I go to a workout and my bench was just lathered with crap, and I'm like, this, that's worse for you than, you know, I would rather sit on a bench that has somebody's sweat on it, honestly, than a bench that's still wet from the from them wiping it down with one of these like, you're completely jacking up our our sheets."

Dr. Josh Redd agrees with

Resources

External Resources

Books

  • "The Inflammatory Reset" by Josh Redd, NMD - Mentioned as a guide for lowering inflammatory load and identifying specific food triggers.

Articles & Papers

  • "Schizophrenia and gluten" - Referenced as research articles indicating a link between schizophrenia and gluten.

People

  • Josh Redd, NMD - Guest, runs multiple clinics, author of "The Inflammatory Reset."
  • Carlin Cole - Partner in a previous book publication.
  • Oliver - Founder of Purey.
  • Chris Palmer - Harvard psychiatrist advocating for ketogenic diets for mental health.
  • Harry Adelson - Pioneer in stem cell treatments, medical director's residency mentor.
  • Jared Ament - Neurosurgeon who performs disc replacements.

Organizations & Institutions

  • Purey - Company that produces PW1 whey protein.
  • Johns Hopkins - Institution where Josh Redd's professor conducted stem cell research.

Websites & Online Resources

  • The Inflammatory Reset.com - Website to purchase Josh Redd's book.
  • Purey.com/max - Website for Purey products with a discount code.
  • drinklmnt.com/geniuslife - Website for Element electrolytes with a special offer.

Other Resources

  • PW1 whey protein - A clean, third-party tested whey protein.
  • Element - Electrolyte supplement with sodium, potassium, and magnesium.
  • Alpha Stim - Device that stimulates the vagal nuclei.
  • CGMs (Continuous Glucose Monitors) - Devices used to track blood sugar levels.
  • Peptides - Mentioned as a tool for helping with inflammation and pain.
  • Stem cell injections - Regenerative medicine treatment for injuries and conditions.
  • Disc replacement - Surgical procedure for degenerated spinal discs.
  • Exosomes - Mentioned as a component of stem cell treatments.
  • Wharton's jelly - Umbilical cord stem cells, mentioned as part of a stem cell treatment.
  • PRP (Platelet-Rich Plasma) - Mentioned as part of a stem cell treatment.

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