Oleic Acid's Role in Fat Gain: Context and Quality Matter
TL;DR
- Oleic acid triggers new fat cell creation when it comprises 45% of a high-fat, ultra-processed diet, leading to potential long-term fat loss challenges.
- The issue isn't olive oil itself but the cumulative effect of multiple high-oleic, ultra-processed oils combined with processed foods and sedentary behavior.
- Extra virgin olive oil's polyphenols and antioxidants offer significant heart health benefits and reduce inflammation, counteracting potential downsides of its oleic acid content.
- Creating more fat cells is not inherently harmful; the metabolic danger arises when existing fat cells become overfilled and spill their contents.
- Prioritizing high-quality, minimally processed fats from diverse sources, including EVOO, avocados, and fatty fish, supports metabolic health and balances essential fatty acids.
- Industrial seed oils like soybean, sunflower, and safflower oil are problematic due to high oleic acid content and processing, unlike nutrient-rich extra virgin olive oil.
Deep Dive
Recent headlines linking olive oil to fat gain are misleading, stemming from a Yale study that tested oleic acid in isolation under high-fat, ultra-processed conditions, not moderate extra virgin olive oil (EVOO) intake as part of a balanced diet. The study's finding that oleic acid can trigger fat cell hyperplasia (multiplication) is significant, but its implications are often misinterpreted. The actual drivers of fat gain are caloric surplus, processed foods, and sedentary behavior, with the problematic oils in the study being industrial seed oils like soybean and sunflower oil, not EVOO.
The critical distinction lies between the isolated oleic acid in the study and the complex composition of high-quality EVOO. While oleic acid can signal fat cells to multiply, EVOO also contains beneficial polyphenols and antioxidants that reduce inflammation, protect cells, and support cardiovascular health. These compounds are largely absent in the refined industrial seed oils used in the research, which are prevalent in processed foods and restaurant meals due to their low cost. Therefore, the issue is not EVOO itself, but the overconsumption of multiple high-oleic, ultra-processed oils combined with excessive calorie intake and lack of physical activity. The Mediterranean diet, which includes moderate EVOO intake, has been consistently linked to reduced cardiovascular disease risk, demonstrating that context and quality are paramount.
The takeaway is that fat gain is driven by overall diet and lifestyle, not a moderate drizzle of quality EVOO. Prioritizing high-quality, minimally processed fats--including EVOO, avocados, nuts, seeds, and omega-3 rich fish--while avoiding industrial seed oils and maintaining a caloric balance is key to metabolic health. Furthermore, the study's finding about fat cell hyperplasia should not be viewed as inherently negative; the real danger lies in overfilled fat cells that spill their contents, contributing to metabolic disease. Having more fat cells, when not overfilled, is not necessarily detrimental. Thus, the focus should remain on a balanced diet, quality fat sources, and an active lifestyle, rather than discarding healthy fats like EVOO based on sensationalized headlines.
Action Items
- Audit dietary fat sources: Identify and replace 3-5 common ultra-processed seed oils (e.g., soybean, sunflower) with high-quality extra virgin olive oil (EVOO) or other minimally processed fats.
- Create fat cell education module: Explain to 5-10 team members the difference between hypertrophy and hyperplasia, and the role of fat cell fullness in metabolic health.
- Measure fat intake balance: Track monounsaturated, polyunsaturated (omega-3 and omega-6), and saturated fat intake for 2-3 weeks to ensure a balanced ratio, avoiding excess oleic acid from processed sources.
- Evaluate oil storage practices: Review and implement guidelines for storing 3-5 types of oils in small, dark bottles to preserve nutrient integrity and prevent oxidation.
Key Quotes
"The study found that the fatty acid composition of oils influences whether fat cells simply grow hypertrophy get bigger or multiply hyperplasia create more of them oleic acid was the only fatty acid tested that could drive new fat cell creation at physiological levels the study found that this occurred when diets were designed with about a 45 total caloric load from fat with oleic acid as the main fat source and the reason they did it this way is they were going to reproduce the high fat high oleic load diet that you see in the ultra processed western diet not of course the mediterranean diet so we're not talking a drizzle of authentic evoo on a salad this study was modeling the kind of fat you'd get from a western diet that's like 70 processed foods with a load of different oa rich seed oils stacked together"
This quote explains the core finding of the Yale study, differentiating between fat cell hypertrophy (growth) and hyperplasia (multiplication). JJ Virgin highlights that oleic acid was the only fatty acid shown to trigger new fat cell creation under specific, high-fat, processed-food conditions, emphasizing this was a model of a Western diet, not typical Mediterranean consumption.
"The oils that were found to be problematic were soybean oil sunflower oil safflower oil and peanut oil and by the way soybean oil is the number one oil that we eat here in the united states they stated it all of oil in the study but it really was these other oils that were used to mimic that 45 of fat in the standard american diet due to the high intake again of ultra processed foods and they also shared their concerns for high oleic canola and soybean oils"
JJ Virgin clarifies which specific oils were identified as problematic in the study, noting that while olive oil was mentioned, the issue stemmed from other high-oleic, ultra-processed seed oils common in the American diet. The speaker points out that soybean oil is the most consumed oil in the U.S. and that concerns were also raised about high-oleic canola and soybean oils.
"Here's the reality yes evoo is high in oleic acid but so are other common oils canola sunflower safflower oil are major sources of oleic acid especially giveaway when the label says high oleic these seed oils often show up in all these different processed foods and dressings and of course restaurant meals because they're cheap if it says high oleic on the label guess what it is it's high oleic like evoo is but without all the good stuff that evoo has because evoo has all these other things which i'll talk to you about in a bit"
JJ Virgin explains that while extra virgin olive oil (EVOO) contains oleic acid, so do many other common oils like canola, sunflower, and safflower, particularly those labeled "high oleic." The speaker emphasizes that these seed oils are often found in processed foods and restaurant meals due to their low cost, and crucially, they lack the beneficial compounds present in EVOO.
"The mediterranean diet includes evoo somewhere like two to four tablespoons a day in moderation and of course the mediterranean diet isn't just about olive oil it has whole and processed foods that are rich in fiber polyphenols omega 3s and a whole bunch of plant diversity and what it doesn't have are things like canola oil sunflower oil soybean oil and safflower oil"
JJ Virgin contrasts the moderate consumption of EVOO within the Mediterranean diet with the problematic oils. The speaker notes that the Mediterranean diet is a comprehensive eating pattern rich in fiber, polyphenols, and omega-3s, and importantly, it excludes oils like canola, sunflower, soybean, and safflower.
"Unlike other high oa oils extra virgin olive oil is unique it doesn't just deliver oleic acid it's also packed with some amazing polyphenols along with any oxins and vitamin e and altogether these compounds support heart health they calm inflammation and they protect your cells in fact olive oil is one of the most studied fats for cardiovascular health randomized clinical trials large cohort studies and meta analysis all support its role in lowering cardiovascular disease improving lipid profiles and reducing mortality"
JJ Virgin highlights the unique benefits of extra virgin olive oil beyond its oleic acid content, explaining that it is rich in polyphenols, antioxidants, and vitamin E. The speaker asserts that these compounds contribute to heart health, reduce inflammation, and protect cells, citing extensive research that supports EVOO's role in lowering cardiovascular disease risk.
"The actual danger isn't having more fat cells when you look at people's metabolic health it's not problematic when you have more fat cells it's problematic when your fat cells get too full that's actually the issue one of the issues with visceral adipose tissue and if you've been listening to anything on my channel you know i'm always railing on visceral adipose tissue and telling you i want you to do a really good waist measurement weekly a waist to hip and a waist to height because that's how we can monitor that you're losing that visceral adipose tissue that's that fat around your organs"
JJ Virgin presents a counterintuitive point about fat cells, stating that the danger is not necessarily having more fat cells but rather having fat cells that become overfilled. The speaker emphasizes that this overfilling is particularly problematic with visceral adipose tissue, the fat surrounding organs, and advises monitoring waist measurements to track its reduction.
Resources
External Resources
Books
- "The New England Journal of Medicine" - Mentioned in relation to a study that found a Mediterranean diet with extra virgin olive oil lowered the risk of major heart events by about 30%.
Research & Studies
- 2025 Yale Cell Reports study - Tested how oleic acid triggered fat-cell hyperplasia under specific high-fat, high-processed-food conditions.
- UK Biobank data - Showed higher blood oleic acid linked to greater obesity risk.
People
- Dr. Rota Heffers - Led the Yale study on oleic acid and fat cell creation.
- Dr. Ben Bickman - Scientist studying insulin and mitochondria, whose work suggests that having more fat cells is not inherently problematic.
Organizations & Institutions
- Yale - Conducted the 2025 Cell Reports study on oleic acid.
- NIH (National Institutes of Health) - Provided funding for the Yale study.
- Cell Reports - A top peer-reviewed journal where the Yale study was published.
Websites & Online Resources
- subscribetojj.com - Website to subscribe for an ad-free podcast experience.
- jjvirgin.com/oliveoil - Provided for full show notes and links.
- megaphone.fm/adchoices - Link for ad choices.
- americanexpress.com/businessplatinum - Website to learn more about American Express Business Platinum.
- 1800contacts.com - Website to save on first order of contacts.
- mintmobile.com - Website to switch to Mint Mobile's unlimited wireless plan.
Other Resources
- Mediterranean diet - Discussed as a diet that includes EVOO and is rich in fiber, polyphenols, omega-3s, and plant diversity.
- Western diet - Characterized by high intake of ultra-processed foods and stacked high-oleic, ultra-processed oils.
- Oleic acid - A fatty acid that can trigger new fat cell creation.
- Hypertrophy - The increase in size of fat cells.
- Hyperplasia - The multiplication or creation of new fat cells.
- Polyphenols - Compounds found in EVOO that support heart health and reduce inflammation.
- Antioxidants - Compounds found in EVOO that support heart health.
- Omega-3s - A type of healthy fat.
- Medium chain triglycerides (MCTs) - Fats found in coconut oil and MCT oils that are easy to burn and good for the brain.
- Visceral adipose tissue - Fat around the organs, which is problematic when fat cells become too full and spill out.
- Seed oils - Including soybean oil, sunflower oil, safflower oil, and peanut oil, which were found to be problematic in the study.
- Extra virgin olive oil (EVOO) - Highlighted for its polyphenols and antioxidants, in addition to oleic acid.
- Industrial seed oils - Oils used in the research that are high-oleic and ultra-processed.
- High-oleic canola and soybean oils - Oils that raised concerns in the study.
- Ghee - A type of saturated fat mentioned as not triggering fat cell hyperplasia.
- Coconut oil - A source of medium chain triglycerides.
- Grass fed butter - A type of saturated fat mentioned as not triggering fat cell hyperplasia.
- Avocado oil - A source of monounsaturated fats.
- Sesame oil - Mentioned as a cooking oil.
- Avocado oil - Mentioned as a monounsaturated fat source.
- Primal Kitchen dressings - Mentioned as a dressing option.
- Coconut oil - Mentioned as a fat source.
- MCT oil - Mentioned as a fat source.
- Fresh Pressed Olive Oil Club - A company providing sourced small farm olive oil.
- T.J. (The Olive Oil Hunter) - Known for sourcing olive oil from small farms.
- Canola oil - Mentioned as a cheap oil often blended with EVOO.
- Wild salmon - A source of omega-3s.
- Sardines - A source of omega-3s.
- Flax, hemp, chia - Sources of omega-3s.
- Nuts and seeds - Sources of omega-6s.
- Grass fed beef - A source of omega-3s and omega-6s.
- Monster Zero Ultra - A line of zero sugar energy drinks.
- American Express Business Platinum - A membership offering business and travel value.
- Dell, Hilton, Adobe - Brands where statement credits can be used with American Express Business Platinum.
- 1800 Contacts - A company providing contact lenses.
- Wayfair - A home goods retailer.
- Monster Energy - A brand of energy drinks.
- Mint Mobile - A mobile virtual network operator.