The 2--2--2 Rule, Bioelectric Medicine, and AI's Future
#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello
Resources
Books
- "Awareness" by Anthony de Mello - A book recommended by Tim, focusing on core truths applicable to practice and meditation.
- "Stop Fixing Yourself Wake Up All Is Well" by Anthony de Mello - A book that discusses self-awareness and finding peace, with some overlap with "Awareness."
- "The Mind of a Mnemonist" by A.R. Luria - A study exploring the inner world of a man with an extraordinary memory, detailing his strengths and weaknesses.
- "Why We Sleep" by Matthew Walker - A book about sleep science, referenced in the discussion about DORAs.
- "The End of Alzheimer's" by Dale Bredesen - A book discussing dementia and a protocol for stabilizing and reversing cognitive decline.
- "Excellent Advice for Living" by Kevin Kelly - A compilation of pithy quotes and advice from Kevin Kelly.
- "Fierce Intimacy" by Terry Real - An audiobook recommended for its insights into relationships and communication.
- "Nonviolent Communication" by Marshall Rosenberg - A book offering frameworks and principles for effective communication in relationships.
Videos & Documentaries
- "Searching for Bobby Fischer" - Mentioned as the basis for a book and movie about chess prodigy Josh Waitzkin.
Research & Studies
- Dual Orexin Receptor Antagonist (DORA) research - Discussed in relation to sleep medication and potential preventative strategies for Alzheimer's.
- Accelerated Transcranial Magnetic Stimulation (aTMS) research - Investigated for its effects on anxiety and depression.
- D-cycloserine (DCS) research - Studied for its potential to enhance cognitive function and treat neuropsychiatric conditions, particularly in conjunction with aTMS.
Tools & Software
- Magventure Device - A device used for accelerated transcranial magnetic stimulation (aTMS).
- Oura Ring - A wearable device for tracking sleep and health metrics like HRV.
- Notion - Software that has added AI features for note-taking, transcription, and querying documents.
- Gemini (built into G Suite) - Google's AI suite that can transcribe meetings and create notes.
- NotebookLM - A tool from Google where users can input documents and ask questions of the content, or create podcast primers.
- Obo.fyi - A platform that creates custom learning courses based on user input.
- The Way App - A meditation app offering guided sessions.
- Elgato Wave 3 - A travel microphone with a sleek design and good noise cancellation.
- Elgato Prompter - A small teleprompter controlled by an iPhone or iPad.
- Tank M3 Push Sled - A high-quality, versatile sled for physical training.
- Rubs Ball - A small ball for rolling out feet to aid relaxation and reduce tension.
- Bonsai Nano Blocks - Small, detailed building blocks used to create bonsai tree models.
- Maistri House Rechargeable Milk Frother - A high-quality, rechargeable milk frother for coffee and other beverages.
- Alpha Ball by Tune Up Fitness - A softball-sized ball for rolling out hips and other body parts.
Articles & Papers
- P Tau test - A blood test to detect elevated levels of tau proteins, indicative of potential dementia.
People Mentioned
- Anthony de Mello - Jesuit priest and psychotherapist, author of "Awareness" and "Stop Fixing Yourself Wake Up All Is Well."
- Dr. Kevin Tracey - Interviewed regarding legitimate vagus nerve stimulation.
- Nolan Williams - Developer of accelerated TMS, sadly deceased.
- Josh Waitzkin - Chess prodigy and author, known for his unique learning frameworks.
- Matthew Walker - Scientist and author of "Why We Sleep," an expert in sleep science.
- Dale Bredesen - Scientist studying dementia and author of "The End of Alzheimer's."
- David Bazay - Co-founder and CEO of Roblox, whose foundation funds research in metabolic therapies.
- Kevin Kelly - Founding editor of Wired magazine, author of "Excellent Advice for Living."
- Rumi - 13th-century Persian poet, whose poetry is compiled in the book "Gold."
- Hala Eliza Ghafuri - Translator and poet of Persian descent, responsible for new translations of Rumi's poetry.
- Henry - Creator of The Way App, a Zen Master.
- Chris Saka - Mutual friend and founder of Obo.fyi.
- Marshall Rosenberg - Author of "Nonviolent Communication."
- Terry Real - Author and therapist specializing in relationships, author of "Fierce Intimacy."
Organizations & Institutions
- Caledonia Spirits - Producer of Barr Hill Gin.
- Stanford University Brain Stimulation Lab - A lab where research has been funded.
- Sisy Foundation - Kevin Rose's foundation that funds research.
- Anthropic - AI company.
- Google - AI company.
- OpenAI - AI company.
- Meta - AI company.
- Perplexity - AI company.
- Nvidia - Company producing GPUs.
- AMD - Company producing GPUs.
- Microsoft - Company involved in AI and data centers.
- Amazon - Company involved in AI and data centers.
- Salesforce - Company implementing AI mandates.
- Exploding Kittens - Game company that collaborated on the game Coyote.
- Eight Sleep - Company producing sleep technology products.
- ClosI - Company producing prescription eye drops.
- Tune Up Fitness - Company producing fitness accessories like the Alpha Ball.
- Braun - Design company known for its aesthetic.
Websites & Online Resources
- Barr Hill Gin (barrhillgin.com) - Producer of the gin mentioned.
- ClosI.com/tim - Website to find an eye doctor and learn about ClosI.
- eightsleep.com/tim - Website for Eight Sleep products, offering a discount.
- davidprotein.com/tim - Website for David protein bars, offering a discount.
- coyotegame.com - Website for the card game Coyote.
- tim.blog/friday - Website for Tim Ferriss's Five Bullet Friday newsletter.
- sanbar.com - Website for Sanbar, a company developing AI companion devices.
- obo.fyi - Website for Obo, a platform for creating custom learning courses.
- thewayapp.com/tim - Website for The Way App, offering free meditation sessions.
Other Resources
- 2-2-2 Rule - A personal rule for alcohol consumption: maximum two drinks on any given night, never two days in a row, and two days a week.
- Aphantasia - The inability to voluntarily visualize mental images.
- Hyperphantasia - The ability to visualize mental images with extreme vividness.
- Synesthesia - A condition where stimulation of one sense leads to involuntary experiences in a second sense.
- GLP-1 agonists (Tirzepatide, Mounjaro, Ozempic) - Medications mentioned in relation to reduced desire for caffeine and alcohol.
- Ketogenic diet - A diet focused on high fat, moderate protein, and low carbohydrate intake.
- Exogenous ketones - Ketone supplements used for potential cognitive benefits.
- Type 3 Diabetes - A term sometimes used for Alzheimer's disease due to its connection with metabolic dysfunction.
- Coyote (card game) - A card game developed by Tim Ferriss and Exploding Kittens.
- AI Stack - A personal collection of AI tools and services used for various tasks.
- Nothing Phone - A smartphone that pairs with Sanbar's AI features.
- Hinge - A dating app.
- Rapa (Rapamycin) - A drug mentioned in relation to potentially increasing lifespan in dogs.