Unlock Longevity: Healthspan, Not Just Lifespan
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Books
- "Outlive" by Peter Attia - This book is mentioned as containing detailed descriptions of concepts like physical, cognitive, and emotional death, and personal anecdotes related to the centenarian decathlon.
Videos & Documentaries
- Matt Walker Episodes - Referenced as a source of in-depth information on sleep, with the podcast having dedicated episodes with Matt Walker.
Research & Studies
- Epidemiologic trials - Mentioned as a source of data supporting the log-linear reduction in ASCVD as ApoB goes down.
- Mendelian randomization studies - Cited as a source of data supporting the log-linear reduction in ASCVD as ApoB goes down.
- Randomized controlled experiments (RCTs) - Discussed as a foundational tool for Medicine 2.0, allowing it to flourish.
- Somatic mutations - Explained as mutations that occur in normally developed cells, contributing to cancer development.
Tools & Software
- Dexa scan - Used to assess body composition (subcutaneous fat, visceral fat, muscle mass) at the outset of patient evaluation.
- CPAP - A mechanical assistance device mentioned for individuals with sleep apnea.
- Cognitive Behavioral Therapy for Insomnia (CBT-I) - A field of behavioral therapy dedicated to cognitive tools for managing insomnia.
Articles & Papers
- Content on Lp(a) - Mentioned as something the podcast has covered extensively, related to cardiovascular disease.
People Mentioned
- Bert Vogelstein - Mentioned as a scientist who suggests that bad luck plays a significant role in cancer development.
- Francis Bacon - Credited with codifying the scientific method in the 17th century, which later became germane to medicine.
- Matt Walker - A friend of the host and an expert on sleep, whose work has increased societal awareness of its importance.
- Arianna Huffington - Mentioned for bringing attention to the importance of sleep.
Organizations & Institutions
- Ten Squared - A company started by the host and others, geared towards training people for the centenarian decathlon.
Courses & Educational Resources
- Podcast episodes on specific topics - The podcast frequently references its own past episodes as deeper dives into subjects briefly touched upon in this episode.
Websites & Online Resources
- peterattiamd.com/subscribe - The website to visit for information on the premium membership benefits.
- peterattiamd.com/about - The website where the host keeps an up-to-date list of all his disclosures.
- YouTube, Instagram, and Twitter (handle: peterattiamd) - Social media platforms where the host can be found.
- Apple Podcasts - A platform where listeners can leave reviews for the podcast.
Other Resources
- The Four Horsemen of Death - A framework used to describe the leading causes of death: atherosclerotic diseases (cardiovascular disease, cerebrovascular disease), cancer, neurodegenerative diseases, and metabolic diseases.
- The Centenarian Decathlon - A mental model for training, focusing on the athletic events one wants to be able to perform at the end of life.
- Medicine 1.0, 2.0, and 3.0 - Frameworks describing historical and future approaches to medicine.
- Lifespan - Defined as the duration of life, a discrete and objective vector.
- Healthspan - Defined as the quality of life, comprising physical, cognitive, and emotional components, and is a variable vector.
- Anabolic resistance - A phenomenon in aging where the body's response to protein intake for muscle building decreases.
- Energy balance (calories) - Stated as the single most important input from nutrition to overall health.
- Protein requirements - Identified as the macronutrient with the least flexibility, with a recommended average of 1.6 grams per kilogram of body weight.
- Dietary restriction - A strategy to reduce caloric intake by removing specific foods from the diet.
- Time restriction - A strategy to induce a caloric deficit by limiting the eating window.
- Sleep deprivation - Highlighted for its significant negative impact on cognition, physical performance, and health markers.
- Exogenous molecule - A substance introduced into the body from external sources, such as drugs and supplements, which should be evaluated for their impact on lifespan or healthspan.