Integrative Hormone Therapy Requires Addressing Toxic Burden First
TL;DR
- Xenoestrogens, present in common products like fragrances and plastics, mimic estrogen and can irreversibly bind to estrogen receptors, leading to physiological estrogen dominance and disrupting hormonal balance.
- A high toxic burden can impede fat loss because the body sequesters toxins in fat tissue and will not release the fat if the liver cannot effectively process the toxins.
- Hormone replacement therapy, particularly estrogen, can backfire in individuals with compromised metabolic health and compromised detoxification pathways, leading to adverse and "messy" outcomes.
- Effective hormone replacement therapy necessitates an integrative approach, addressing metabolic health, stress, sleep, diet, and exercise, not just hormone supplementation.
- Chronic exposure to airborne toxins from sources like air pollution, household products, and combustion byproducts can significantly impact overall health, including lung function and hormonal balance.
- Prioritizing avoidance of toxic exposures, such as fragrances, plastics, and certain cleaning products, is the primary rule in environmental medicine for managing toxic burden.
- Investing in air and water filtration systems, alongside choosing low-VOC or natural home materials, are controllable variables that significantly mitigate indoor toxic exposure.
Deep Dive
The central argument is that hormone replacement therapy (HRT), particularly estrogen, can backfire and exacerbate health issues when individuals have a high toxic burden. This occurs because environmental toxins, known as xenoestrogens, mimic estrogen, overload the body's detoxification pathways, and disrupt hormonal balance, leading to symptoms often misattributed solely to hormone deficiency.
The implications of this toxic burden extend beyond hormonal imbalances to affect broader metabolic health, including the ability to lose weight. Toxins sequester in fat cells, and if the liver cannot effectively process them, the body will not release the fat, creating a significant obstacle for weight loss efforts, regardless of other interventions like GLP-1 medications. Furthermore, the pervasive presence of xenoestrogens from everyday products like fragrances, plastics, beauty products, and household items means that simply introducing exogenous hormones without addressing the body's detoxification capacity and environmental exposures is an incomplete and potentially harmful approach. The episode emphasizes that an integrative approach, focusing on mitigating exposures and supporting detoxification, is crucial for safe and effective hormone management and overall health.
The critical takeaway is that effective and safe hormone therapy requires a foundational approach that prioritizes the body's detoxification systems and minimizes exposure to environmental toxins. Without this integrative strategy, interventions like HRT risk worsening existing problems or creating new ones by introducing hormones into a system already compromised by a high toxic load. Therefore, controlling environmental exposures and supporting metabolic and liver health are not optional but essential prerequisites for hormonal well-being.
Action Items
- Audit personal product usage: Identify and replace 3-5 high-toxin items (e.g., fragrances, dark hair dyes, aerosol sprays) with safer alternatives.
- Implement home air filtration: Install high-quality air scrubbers in at least 2 primary living/sleeping areas to reduce airborne toxins.
- Evaluate home furnishings: Assess 3-5 common household items (e.g., furniture, rugs, cleaning products) for potential off-gassing or toxic components.
- Minimize plastic exposure: Replace 5-10 everyday plastic items (e.g., food containers, water bottles) with glass or metal alternatives.
- Review laundry practices: Swap out fabric softeners and dryer sheets for wool dryer balls and a simple, clean detergent.
Key Quotes
"Everyone wants to talk about hormones right now. Estrogen, HRT, menopause, fixes. What almost no one is talking about is the environment those hormones are being dropped into. In this episode, I break down what happens when estrogen enters a body with a high toxic load, and why hormone therapy can backfire when your detox pathways, liver, and metabolic health are compromised."
Dr. Tyna Moore explains that the common focus on hormones like estrogen and HRT overlooks a critical factor: the body's internal environment. She emphasizes that hormone therapy can be ineffective or even detrimental if the body's detoxification systems, liver function, and overall metabolic health are compromised by a high toxic load.
"The number one rule in environmental medicine is avoidance avoidance avoidance the number one rule is to not get exposed to it in the first place so we cannot control that we live in a toxic planet it's very it's very toxic you guys and it is a toxic soup some places are worse than others we can't control that we can't control what our government does we can't control what other governments do we can't control what china's burning and polluting into the atmosphere we can't control what india is doing there are some countries creating a lot of pollution we can't control it."
Dr. Tyna Moore highlights that the primary principle in environmental medicine is to avoid exposure to toxins. She acknowledges that complete avoidance is challenging due to widespread environmental pollution, which is beyond individual control, including governmental actions and global industrial practices.
"If you are having a hard time losing fat off your body despite your best efforts that is usually a sign of toxic burden because our the toxins will sequester in the fat and that is where they are housed and if the liver can't handle them your body will not release them meaning it will not release the fat."
Dr. Tyna Moore points out that persistent difficulty in losing body fat, even with dedicated efforts, often indicates a high toxic burden. She explains that toxins accumulate in fat tissue, and if the liver cannot process them, the body will retain the fat as a storage mechanism.
"Xenoestrogens basically are their fake estrogens that in some cases irreversibly bind the estrogen receptor and they're very difficult to get off and then they that they tell the estrogen receptor to go except it's not real estrogen so that's not great some common sources are fragrances and perfumes as I mentioned I that's a big one guys just stop I I 100 would suggest people stop wearing perfume."
Dr. Tyna Moore defines xenoestrogens as synthetic compounds that mimic estrogen and can bind to estrogen receptors, sometimes irreversibly. She identifies fragrances and perfumes as significant sources of these xenoestrogens and strongly advises against their use due to their disruptive effects.
"The number one rule in environmental medicine is avoidance avoidance avoidance the number one rule is to not get exposed to it in the first place so we cannot control that we live in a toxic planet it's very it's very toxic you guys and it is a toxic soup some places are worse than others we can't control that we can't control what our government does we can't control what other governments do we can't control what china's burning and polluting into the atmosphere we can't control what india is doing there are some countries creating a lot of pollution we can't control it."
Dr. Tyna Moore emphasizes that the foundational principle of environmental medicine is avoidance of toxic exposure. She acknowledges the pervasive nature of toxins in the environment, which are often beyond individual control due to global pollution sources and governmental policies.
"And then of course where you live you know there's humid climates there's not humid climates there's where i live in arizona now there's like a ton of dust and that's a big so there's pm 2 5 which i talked about on the last podcast and then there's pm 10 and pm 10 is like the big more coarse particulate in the air and dust would or the the sandy dust around everything has like dusty sand and it's kind of corrosive and i'm breathing it in when i go for walks with my dogs and i'm outside right so we do the best we can be careful of your vacuum make sure you clean the filters out regularly because you might just be blowing the really fine particulate back out of the vacuum back into the air so you're vacuuming over here but it's blowing stuff you don't want to breathe in out the other side."
Dr. Tyna Moore discusses how geographical location and local environmental factors, such as dust and particulate matter (PM10), contribute to toxic exposure. She also highlights the importance of maintaining household appliances like vacuums, ensuring their filters are clean to prevent re-releasing fine particles into the air.
Resources
External Resources
Books
- "GLP1 Done Right University" - Mentioned as a course containing a module on hormones and the author's clinical rationale for hormone treatment.
Articles & Papers
- "Metabolic disease associated liver disease" (Article on fatty liver) - Discussed as a condition with a high prevalence, indicating compromised liver function in many individuals.
Tools & Software
- Jaspr Air Scrubber - Discussed as a preferred air filtration system for removing VOCs and other airborne toxins.
- AquaTru Water Filter - Referenced as a recommended water filtration system.
- VivaRays Circadian Glasses - Mentioned for their ability to manage light exposure for circadian rhythm and hormonal health.
People
- Dr. Tyna Moore - Host of "The Dr. Tyna Show" and author of the episode.
- Mike Feldstein - CEO of Jaspr, mentioned in relation to previous podcast episodes about air quality and mold.
Organizations & Institutions
- Wellness Loud - Production company for "The Dr. Tyna Show."
Websites & Online Resources
- jaspr.co/DRTYNA - Link for purchasing Jaspr Air Scrubbers with a discount code.
- timeline.com/DRTYNA - Link for purchasing Timeline products with a discount code.
- bioptimizers.com/drtyna - Link for purchasing BIOptimizers products with a discount code.
- paleovalley.com/drtyna - Link for purchasing Paleo Valley products with a discount code.
- drinklmnt.com/drtyna - Link for purchasing LMNT products with a discount code.
- VivaRays.com - Website for purchasing VivaRays glasses with a discount code.
- aquatruwater.com - Link for purchasing AquaTru water filters.
- dr.tina.com/holiday - Link for the author's holiday gift guide.
- wellnessloud.com - Website for more shows by the author's team.
- podcast.dr.tina.com - Email address for the podcast.
- iqair.com - App mentioned for checking local air quality.
- Arizona DEQ - Arizona Department of Environmental Quality, mentioned for regional air quality data.
Other Resources
- Xenoestrogens - Discussed as environmental toxins that mimic estrogen and bind to estrogen receptors.
- Toxic Bucket - A metaphor used to describe an individual's cumulative toxic burden.
- MTHFR status - Mentioned as a factor contributing to an individual's toxic burden.
- Mitophagy - A cellular process mentioned in relation to mitochondrial health and aging, supported by Urolithin A.
- Urolithin A - A compound mentioned for its benefits in supporting mitochondrial health and healthy aging.
- GLP-1 - A class of drugs mentioned in the context of hormone therapy and metabolic health.
- Pesticides - Mentioned as a source of xenoestrogens.
- Parabens - Mentioned as a source of xenoestrogens.
- Microplastics - Mentioned as a source of toxins.
- Formaldehyde - Mentioned as a component in furniture and building materials.
- Flame retardants - Mentioned as a component in furniture and textiles.
- VOCs (Volatile Organic Compounds) - Discussed as airborne toxins released from various household products.
- PM 2.5 and PM 10 - Types of particulate matter in the air, discussed in relation to air quality.
- Glyphosate - Mentioned as a toxic chemical used in agriculture.
- Chlorine gas - Discussed as a toxic gas created by mixing bleach and vinegar.
- Obeseogens - A term for toxins that contribute to obesity, related to xenoestrogens.
- Diabesogens - A term for toxins that contribute to diabetes, related to xenoestrogens.