Unlocking Biological Age: Beyond Epigenetics to Future Clocks

Resources

Resources & Recommendations

Books

• "Unquiet" by Linn Ullmann - A novel by the daughter of Liv Ullmann and Ingmar Bergman, featuring sections about Ingmar Bergman's own life and interviews between Linn and her father, touching on themes of life trajectories and aging.
• "Fresh Water for Flowers" by Valérie Perrin - A novel about a woman named Violet who is a caretaker at a cemetery in France, exploring themes of death, life, and the people she encounters.
• "The Year of Magical Thinking" by Joan Didion - A strong memoir about the author's year of mourning her husband's death and her daughter's illness, praised for its unique language and prose.
• "Mot döden" (The Case Against Death) by Patrick - A philosophical argument for why life is good and death is bad.

Research & Studies

• Steve Horvath's 2013 paper in Genome Biology - This foundational work identified a strong association between epigenetic data and age, leading to the development of epigenetic clocks.
• Study on mice using epigenetic reprogramming to improve clinical symptoms (e.g., retina of the eye) - Mentioned as an example of experimental validation for cause and consequence in aging research, though not confirmed to extend lifespan.
• UK Biobank study on facial aging and telomere length - A study conducted by Sara Hägg's group that found an association between perceived older facial age and shorter telomeres, a biomarker of cellular aging.

People Mentioned

• Sherelle Dorsey - Host of TEDTech, where she explores innovations and ideas in the tech world.
• Juan M. Lavista Ferres - AI for Good Executive from Microsoft, interviewed on TEDTech.
• Jacqueline Novogratz - Impact investor and CEO of Acumen, interviewed on TEDTech.
• Josephine Waweru - Farmer and community builder from Kenya, interviewed on TEDTech.
• Dr. Sara Hägg (Karolinska Institutet) - Leads the Molecular Epidemiology of Aging group, a leading researcher in biological age clocks.
• Steve Horvath - Pioneer in the field of epigenetic clocks, published foundational work in 2013.
• Brian Johnson - A longevity influencer known for tracking and attempting to reverse his biological age.
• Linn Ullmann - Norwegian author, daughter of Liv Ullmann and Ingmar Bergman, author of "Unquiet."
• Liv Ullmann - Norwegian actress and director.
• Ingmar Bergman - Famous Swedish director, known for films exploring themes of death.
• Valérie Perrin - French author of "Fresh Water for Flowers."
• Joan Didion - American writer, author of "The Year of Magical Thinking."
• David Sinclair - Researcher known for his work in aging, whose lab collaborated with Biostate AI.

Organizations & Institutions

• Karolinska Institutet - Institution where Dr. Sara Hägg leads the Molecular Epidemiology of Aging group.
• Swedish Twin Registry - The largest twin registry in the world, a rich source of data for research.
• UK Biobank - A population-based cohort of half a million individuals with collected data on biomarkers, genetics, proteins, and health-related questions.
• Nordic Aging Society - An organization that holds annual meetings to foster collaboration and interest in aging research across Nordic countries.
• Biostate AI - A company that claims to have created an AI scientist called Cadence, which collaborated with David Sinclair's lab.

Tools & Software

• Software from Steve Horvath - Codes and software made available by Steve Horvath for researchers to develop and apply epigenetic clocks to their own data.
• DunedinPACE - One of the epigenetic clocks mentioned as being used by Brian Johnson.
• Cadence - An AI scientist developed by Biostate AI, used in collaboration with David Sinclair's lab to accelerate discovery in aging research.