CZI Fuels Disease Cures with AI and Biology Fusion
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Books
- "The Periodic Table" by Primo Levi - Mentioned as an analogy for the unknown number of cell types in a human, similar to how the periodic table lists all known elements.
Videos & Documentaries
- N/A
Research & Studies
- Cell Atlas Project - A project initiated by CZI to understand all the different configurations of every cell in the body, contributing significantly to biological data.
- AlphaFold - A protein structure prediction model developed by DeepMind, mentioned as an example of frontier AI leveraging decades of publicly available data.
- Billion Cell Project - A current project building upon the success of the human cell atlas, aiming to generate a large corpus of cell data more rapidly and at a lower cost.
Tools & Software
- ESM3 - One of the top protein models, developed by the Evolutionary Scale team.
- See-through fish (zebrafish) - Used as a model organism for imaging living things, with models helping to translate findings to human biology.
- CRISPR - Mentioned as a technology that people should ramp up on, highlighting its importance in future biological research.
- CAR T-cells - A form of immunotherapy where T-cells are reprogrammed to fight cancer, mentioned as an example of cellular engineering with clinical impact.
- Diffusion model for generating cells - A model released by CZI that allows for the generation of synthetic cells based on described conditions.
Articles & Papers
- N/A
People Mentioned
- Bill Gates - Mentioned as a mentor to Priscilla Chan.
- Garrett - A biologist mentioned as using models like SAM.
- Alex Reeves - Will be running the AI program at the newly unified biohub following the joining of the Evolutionary Scale team.
Organizations & Institutions
- Chan Zuckerberg Initiative (CZI) - The organization founded by Priscilla Chan and Mark Zuckerberg, focused on science and education.
- Chan Zuckerberg Biohub - An organization pioneered by CZI, focused on bringing together scientists and AI researchers to advance basic science.
- Gates Foundation - Mentioned for its strong focus on translational research and public health.
- NIH - Mentioned as the largest investor in basic science through grants to individual investigators.
- Meta - Mentioned as a previous employer of Mark Zuckerberg, where he gained experience in organizing teams.
- Stanford, UCSF, and Berkeley - Universities involved in the first Biohub.
- DeepMind - The organization that developed AlphaFold.
- Evolutionary Scale team - A renowned team working on AI and biology, known for protein models like ESM3, joining CZI.
Courses & Educational Resources
- N/A
Websites & Online Resources
- SAM (from Meta) - A model mentioned as being used by biologists.
Other Resources
- Virtual Immune System - A goal of CZI's research, involving modeling the complex interactions within the immune system for therapeutic and preventative applications.
- Virtual Cell Models - The primary tool being developed by CZI, aiming to simulate cellular behavior and aid in scientific discovery and therapeutic development.