Unlock Untapped Cures: The Power of Repurposed Drugs

Resources

Books

• "Protocols: An Operating Manual for the Human Body" by Andrew Huberman - This is the host's upcoming book, covering science-based tools for various aspects of health.

Videos & Documentaries

• Ted talk by Dr. David Fajgenbaum - Mentioned as a way to learn more about his work and raise awareness.

Research & Studies

• "Cell" paper on sleep deprivation in mice - This study showed that sleep deprivation led to cytokine storms and immune system overactivity in mice, potentially relevant to autoimmune flares.
• Study on PD-L1 expression in angiosarcoma tumors - This 2013 paper found increased PD-L1 expression in angiosarcoma tumors, which later led to testing PD-1 inhibitors for the condition.

Tools & Software

• AI Platform/Machine Learning Models - Used by Every Cure to quantify the likelihood of every drug treating every disease.
• PubMed - A database used for searching scientific literature, mentioned as a resource for finding information on treatments.
• Biomedical Knowledge Graphs - A concept used by Every Cure to map the world's knowledge of human biology.

Articles & Papers

• Paper on Tnf Inhibitors and Dada2 - Mentioned as a case where a doctor treated a child with Dada2 using a Tnf inhibitor, leading to the child stopping having strokes.
• Paper on PD-L1 expression in angiosarcoma tumors - This 2013 paper found increased PD-L1 expression in angiosarcoma tumors, which later led to testing PD-1 inhibitors for the condition.

People Mentioned

• Dr. David Fajgenbaum - Guest on the podcast, professor of translational medicine and human genetics at the University of Pennsylvania, founder of Every Cure.
• Dr. Benjamin Castleman - Physician after whom Castleman's disease is named.
• Dr. Kazuhiro Yoshizaki - Discovered the drug Tocilizumab (Tocilizumab) for Castleman's disease in Japan.
• Chip Chambers - Doctor who, after his children were born with Dada2, researched and helped bring Tnf inhibitors to treat the condition.
• Dr. Luke Chen - A colleague of Dr. Fajgenbaum in hematology who brainstorms treatment options for patients.
• Michael Easter - Author of "The Comfort Crisis," discussed in the context of voluntary hardship and gratitude.
• Dr. Joe Parvizi - Neurosurgeon at Stanford who identified the role of the anterior mid-cingulate cortex in tenacity and leaning into challenges.
• Chris McCarty - Researcher in Florida studying Kratom.

Organizations & Institutions

• University of Pennsylvania - Where Dr. David Fajgenbaum is a professor.
• Stanford School of Medicine - Where Andrew Huberman is a professor.
• Georgetown University - Where Dr. Fajgenbaum was a freshman and played football.
• Oxford University - Where Dr. Fajgenbaum completed a graduate degree.
• Every Cure - A nonprofit organization founded by Dr. David Fajgenbaum to find new uses for existing drugs.
• Castleman Disease Collaborative Network - A foundation started by Dr. Fajgenbaum to support Castleman's patients and research.
• ALS Association - An example of a disease organization.
• Michael J. Fox Foundation for Parkinson's Disease - An example of a disease organization.
• Arpa H (Advanced Research Projects Agency for Health) - A US government agency that is a significant funder of Every Cure.
• Environmental Working Group (EWG) - Referenced for studies on PFAST chemicals and cancer-causing chemicals in tap water.
• UCSF (University of California, San Francisco) - Mentioned in the context of its Chair of Neurosurgery.

Courses & Educational Resources

• Huberman Lab Podcast - The podcast itself is presented as a resource for science-based tools.
• Huberman Lab Newsletter (Neural Network Newsletter) - A monthly newsletter offering podcast summaries and protocols.

Websites & Online Resources

• everycure.org - The website for the nonprofit organization Every Cure.
• everycure.org/ideas - The section of the Every Cure website where people can submit potential drug repurposing ideas.
• everycure.org/experts - The section of the Every Cure website for experts to sign up.
• everycure.org/donate - The donation page for Every Cure.
• protocolsbook.com - The website for Andrew Huberman's book, "Protocols: An Operating Manual for the Human Body."
• drinkagz.com/huberman - Website for AG1's new sleep product, AGZ.
• eightsleep.com/huberman - Website for Eight Sleep mattress covers.
• functionhealth.com/huberman - Website for Function health testing.
• rora.com/huberman - Website for Rora water filters.
• davidprotein.com/huberman - Website for David protein bars.

Other Resources

• Aspirin - Discussed for its pain-relieving effects and potential benefits in offsetting heart attacks and reducing the risk of colon cancer recurrence.
• Viagra (Sildenafil) - Mentioned as a drug repurposed from heart disease to treat erectile dysfunction and a rare pediatric lung disease.
• Cialis (Tadalafil) - Mentioned as a cousin of Viagra, initially used for prostate health and later discovered to have other effects related to sexual function.
• Lidocaine - Discussed as a numbing medicine that, when injected around a breast cancer tumor before surgery, showed a significant reduction in mortality at five years.
• Lithium - Mentioned as a potential protectant for Alzheimer's or other forms of dementia, with some psychiatrists taking low doses.
• Tnf inhibitors - Drugs that inhibit Tumor Necrosis Factor, mentioned in the context of treating Dada2 and Aladalimumab for Castleman's disease.
• Tnf alpha - A cytokine involved in inflammatory response.
• Dada2 - A rare genetic condition causing numerous strokes in children.
• Tnf inhibitor - A type of drug that inhibits Tnf.
• Tocilizumab (Tocilizumab) - A drug originally developed in Japan for Castleman's disease, later approved in the US for rheumatoid arthritis and other autoimmune diseases.
• Adria mycin - A chemotherapy drug.
• Taxotere - A chemotherapy drug.
• Topotecan - A chemotherapy drug.
• Velcade - A chemotherapy drug.
• Xeloda - A chemotherapy drug.
• Mycin - A chemotherapy drug (likely referring to a class of drugs).
• Cyclosporine - An immunosuppressant drug, one of two Dr. Fajgenbaum tried for his relapse.
• IvIg (Intravenous Immunoglobulin) - Another drug Dr. Fajgenbaum tried for his relapse.
• Rapamycin (Sirolimus) - An mTOR inhibitor approved for organ transplant rejection, which Dr. Fajgenbaum has been taking for Castleman's disease.
• mTOR pathway - A signaling pathway in the immune system.
• Bachmann Bupp Syndrome - A rare condition where children have elevated levels of the enzyme OCE1, treatable with DFMO.
• DFMO (Eflornithine) - A drug made for African sleeping sickness that can treat Bachmann Bupp Syndrome.
• Colchicine - A drug typically used for gout, with evidence suggesting it can reduce the risk of heart attacks, particularly in individuals with prior heart attacks and diabetes.
• Magnesium three and eight theanine - Supplements that can help with sleep.
• Chamomile extract - A supplement that can help with sleep.
• Saffron - A supplement that can help with sleep.
• Valerian root - A supplement that can help with sleep.
• AGZ - A nightly drink by AG1 designed to help with sleep.
• David protein bars - Protein bars with high protein and low sugar.
• Glialblastoma - A type of brain cancer.
• Vascularitis - Inflammation of blood vessels.
• Interleukin-6 (IL-6) - A cytokine involved in inflammation.
• Poems Syndrome - A rare cancer similar to multiple myeloma.
• Ruxolitinib - A drug used for myelofibrosis, found to be effective for Castleman's disease.
• Melanoma - A type of skin cancer.
• Pembrolizumab - A PD-1 inhibitor now used for dozens of cancers, initially developed for melanoma and lung cancer.
• PD-1 inhibitor - A type of immunotherapy drug.
• PDL1 - A marker that indicates a potential response to a PD-1 inhibitor.
• Angiosarcoma - A type of cancer.
• Open Evidence - A company attempting to create a GPT for healthcare.
• Creatine - A supplement discussed for strength and potential cognitive support.
• Nicorette - Nicotine gum used by a Nobel laureate neuroscientist for potential protection against Alzheimer's and Parkinson's.
• GLP-1s (Glucagon-like peptide-1 receptor agonists) - Drugs that may offer benefits in reducing the risk of Parkinson's, Alzheimer's, and breast cancer.
• Rapamycin (Sirolimus) - Found in soil samples from Rapa Nui (Easter Island), initially investigated as an antifungal, then for immunosuppression, and now used for organ transplant rejection and potentially longevity.
• Kratom - A plant product sold as a natural opioid replacement, which can also be highly addictive.
• Coca plant - Contains alkaloids being tested for pain relief and psychoactive properties.
• Micona purines - A velvety bean that is 99% L-Dopa.
• L-Dopa - A precursor to dopamine.